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Astrocytes maintain their antioxidative functions through two primary mechanisms: the Nrf2keap1antioxidant response element (ARE) pathway and glutathione (GSH) synthesis

Drug-Induced Pigmentation: Medicines can sometimes cause darkening of the lips and surrounding skin

GRX2 mitigates oxidative stress by reducing SSG of NADPH oxidase subunits (NDUFS1/NDUFV1), suppressing mitochondrial ROS overproduction linked to left ventricular hypertrophy and hypertension (79)

So after a lot of work on biohacking and also the neurological and even the spiritual stuff that happens at 40 years of zen and fasting in caves and things like that