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A logical extension of this framework is the consideration of another key regulatory system -the gut microbiota, which also makes a substantial contribution to diabetes pathogenesis and interacts with the islet apparatus within the framework of the gutpancreas axis

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Our data obtained by knocking down GPx1, both in the human HEK293T cells and in rat neurons, together with the in vitro experiments, strongly suggest that endogenous -glutamylcysteine is a GPx1 cofactor for H 2 O 2 detoxification

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