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Accessed May 28, 2025.

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53,54,55 These niche changes include increased expression of inflammatory cytokines such as CXCL14 and cell cycle inhibitors such as CDKN1C and CDKN2A, coupled with downregulation of ECM and adhesion genes, including CAV1 , SPRY1 , FN1 , and ITGB1

In patients with colon cancer, Hcy levels are similarly elevated, and Hcy levels correlate with the patients IL-6, TNF-, and folate levels
