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This reference does not suggest if a nootropic works or not -- but it does explain why it may be categorized as a nootropic, as well as serving as a starting point for additional research

In a 2-year trial involving patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risk, more events of diabetic retinopathy complications occurred in patients treated with semaglutide 0.5 and 1 mg once weekly injections (3%) compared to placebo (1.8%)

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Nevertheless, its vital to reiterate that clinical research in humans is in its infancy, and extensive investigations are needed to validate its safety and effectiveness in treating cardiac conditions