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Kang EA, Han YM, An JM, Park YJ, Sikiric P, Kim DH, et al

a study titled Blockade of mtDNA release ameliorates hepatic IR through avoiding cGAS-STING activation demonstrated that using a pharmacological inhibitor of Bax/Bak (which blocks mtDNA release from mitochondria) reduced liver injury and that adding a STING antagonist likewise protected the liver ( Clinically, strategies to mitigate IR include ischemic preconditioning (clamping the portal triad briefly before a long ischemia), which has been shown to lower postoperative transaminases and reduce cytokine release

Beta-carotene is a provitamin A and a scavenger antioxidant