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doi: 10.1167/iovs.14-14879 175 SzutoriszH.HurdY

Exploiting the computational algorithm, convergent motifs for binding sites (COMBS) for designing a small-molecule binding protein, Dang, DeGrado, and coworkers prepared a highly specific de novo protein, Apixaban binding helical bundle ( ABLE ) and PARP inhibitor binder ( PiB ) proteins for the rapid clearance of the achiral antithrombotic drug apixaban and the anticancer drug rucaparib , respectively (Fig

Vitamin D deficiency has been consistently implicated in OA progression, with lower serum levels inversely correlated with pro-inflammatory cytokines such as IL-1, TNF-, hs-CRP, and NF-B p65, as well as with greater symptom severity [57,58,59,60,61,62]