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Description
T2DM arises from insulin resistance (IR) and -cell dysfunction, leading to impaired glucose uptake despite compensatory hyperinsulinemia, followed by progressive insulin deficiency [6]

Those phosphopeptides with CV above some threshold will be removed
Neuroscience 300 , 128140 (2015)

Remarkable clinical improvements have resulted from these efforts, particularly evident in hydroxyurea's ability to increase HbF, reducing microvascular occlusion, tissue ischemia, and pain
