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They are darker than the surrounding skin because of the melanin
A partir de su unin al pattern recognition receptor, la Hb promueve la activacin de diversas seales de transduccin como las cinasas c-Jun N-terminal, p38 y MAPK33

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Bachier C, Giles RE, Ellerson D, Hanania EG, Garcia-Sanchez F, Haley T, Andreeff M , Cabanillas F, Champlin R, Berenson R, Heimfeld S, Deisseroth AB
