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Recently, we reported that not only the acute infectious phase [25] but also Long COVID [26] is characterized by concurrent elevations in depression (depressed mood, feelings of guilt, suicidal ideation, loss of interest), anxiety (anxious mood, tension, fears, anxiety behavior at interview), chronic fatigue and somatic symptoms including autonomic and gastrointestinal (GIS) symptoms, malaise and muscle pain

10.1016/S0197-0186(01)00122-X Neurochem

For instance, long-term studies with the IL-23-targeting therapy tildrakizumab showed an excellent response over time and long-term maintenance of response

Seshasai SR, Kaptoge S, Thompson A, et al