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The upregulation of HO1 and peroxisome proliferatoractivated receptor coactivator1 (PGC1) caused by ablation of BACH1 may repress the ROS generation, and increased angiopoietin 1 (ANGP1) and fibroblast growth factor 2 (FGF2) in ECs may facilitate the angiogenesis after hindlimb ischemia

Additional inflammation modulating lipid compounds, whose synthesis can also be triggered by aspirin, are the resolvins (Rv) and the protectins (PD) and these are also discussed in the Bioactive Lipid Mediators of Inflammation page

These actions suggest an intracellular mechanism [52, 5456]

[PubMed] [Google Scholar] 214.Das SK, Eder S, Schauer S, Diwoky C, Temmel H, Guertl B, et al