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Abstract Simple Summary Cancer related fatigue is a common and distressing symptom for patients with cancer during and after primary treatment, and also in the palliative phase of the disease trajectory

Since the discovery of nuclear PKC in the nuclei of rat liver,68 there is a growing body of evidence to support the presence of PKC in the nucleus, with specific expression of the isoforms depending on the cell type and differential distribution within subnuclear compartments.69, 70, 71 The PKCs present in the cell nucleus are either translocated from the cytoplasm upon activation or exist constitutively within the nucleus.72 In the immune system, translocation of PKC to the nucleus appears to be the main mechanism in which nuclear PKC regulates immune cell differentiation

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