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Other key pathological changes include mesangial cell proliferation/hypertrophy, and increased production of extracellular matrix proteins [61, 64, 65]

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5.1.4 Selenoprotein F (the 15 kDa selenoprotein) Selenoprotein F (SelF) is a 15kDa thioredoxin-like oxidoreductase localized in the endoplasmic reticulum (ER), containing a quintessential thioredoxin-like fold and having a Cys-X-X-Sec motif, suggesting that they have the redox activity of thiol disulfide bond oxidoreductases (201, 202)