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Drugs targeting TMAO production, such as 3,3dimethyl1butanol (DMB), inhibit microbial enzymes involved in TMA formation

J Endocrinol 238:R79R94

71 Metabolic memory refers to the phenomenon in which early episodes of hyperglycemia leave lasting molecular imprintssuch as epigenetic modifications and persistent activation of signaling pathways (e.g., PKC, NF-B, and transforming growth factor (TGF)-)that drive the progression of diabetic complications even after glycemic control is achieved

Assou S, Girault N, Plinet M, Bouckenheimer J, Sansac C, Combe M et al (2020) Recurrent genetic abnormalities in human pluripotent stem cells: definition and routine detection in culture supernatant by targeted droplet digital PCR