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Shokri M, Sajedi F, Mohammadi Y, Mehrpooya M (2021) Adjuvant use of melatonin for relieving symptoms of painful diabetic neuropathy: results of a randomized, double-blinded, controlled trial

The upregulated expression of ptgs2a and acsl4a induced by FAC treatment, which was subsequently downregulated after DFO intervention, combined with the distinct expression pattern of gpx4a , may suggest that the mechanism underlying FAC-induced ferroptosis is different from that of Erastin, and the mode of ferroptosis rescue by DFO also differs from that of Fer-1

A procedure called Kasai hepatoportoenterostomy (KPE) that replaces the obliterated extrahepatic bile duct with an intestinal conduit is the first-line treatment to re-establish the bile flow with only 50% success rate ( BA is most likely a clinical phenotype resulting from a number of prenatal or perinatal insults to the hepatobiliary tree, and this disease is underpinned by a number of key pathobiological factors (KPFs) either singly or more often in combinations

These insights offer potential targets and a theoretical framework for future developments