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In mice, hypothalamic ER-dependent gene expression changes have been linked to common TAM side effects, including decreased movement (Zhang et al., 2021), which could contribute to weight gain

Where B12 genuinely helps is in people whose levels are low or falling

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Diet, supplements (e.g., niacin, NR), and exercise help, but may not suffice post-40 due to inefficiency and depletion.[18][19] Oral precursors like NMN increase NAD+ but bioavailability varies