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Still, our data raise the possibility of several additional nodes of regulation of the CIA in response to cysteine limitation that are worthy of further exploration, including inhibition of cytosolic cluster synthesis due to cysteine insufficiency, restriction of mitochondrial cluster export, or differential cluster integration into recipient proteins through the regulation of the chaperone-based trafficking system 79

DMF activates NRF2 to inhibit the pro-invasion ability of TAMs in breast cancer

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a d Quantification of reduced glutathione (GSH), oxidized glutathione (GSSG), their ratio, as well as the total concentration of glutathione in brain homogenates from 6 mth-old mice, as quantified by HPLC, for the indicated genotypes