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Despite a clear role of serotonin decreasing uterine and placental vascular perfusion by promoting vasoconstriction of uterine/placental vascular beds 4,45,46,47 , decreased estrogen may also be involved in the decreased perfusion and growth of the placenta as estradiol regulates uteroplacental angiogenesis, endothelial cell proliferation, and vasodilation through genomic and nongenomic pathways 48,49,50

[DOI] [PMC free article] [PubMed] [Google Scholar] 312.Sim J., Lanka S., Jo J.-W., Chaudhary C.L., Vishwanath M., Jung C.-H., Lee Y.-H., Kim E.-Y., Kim Y.-S., Hyun S.-S., et al

Mitochondrial dysfunction in immune cells further drives metabolic exhaustion, manifested as declined OXPHOS in aged T cells and metabolic suppression in tumor-infiltrating T cells

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