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Severe Hypokalemia: A Critical Drop in Potassium Levels One of the most serious complications of B12 replacement therapy in severe megaloblastic anemia (a type of anemia where blood cells are abnormally large) is the development of severe hypokalemia (dangerously low potassium levels in the blood)

Individuals with Gastrointestinal Conditions: Certain gastrointestinal conditions, such as celiac disease, Crohns disease, or gastrointestinal surgery, can impair nutrient absorption

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