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Targeted design includes (i) passive targeting, which capitalizes on the characteristics of the tumor microenvironment (such as increased vascular permeability and impaired lymphatic drainage) to enable nano-formulations to accumulate in tumor sites via the EPR effect
Sanz AB, Sanchez-Nio MD, Ramos AM, Moreno JA, Santamaria B, Ruiz-Ortega M, et al
Q3ME inhibited esophageal tumorigenesis by targeting ERKs and AKT (Zhao et al., 2018a)
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