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Tirzepatide (Mounjaro/Zepbound) already delivers 15-22% body weight loss through dual GIP/GLP-1 receptor activation - making it one of the most powerful single-agent options available
Finally, we compared prioritised variants to the 90 HPRC assembly tracks available on the UCSC Genome browser allele frequencies [11, 31, 32]
Rees, E
Blitzer RD, Connor JH, Brown GP, Wong T, Shenolikar S, Iyengar R et al (1998)
