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[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Tait SW, Oberst A, Quarato G, Milasta S, Haller M, Wang R, et al

Korean traditional herbal formula Soshiho-tang attenuates memory impairment and neuronal damage in mice with amyloid-beta-induced Alzheimer's disease

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Where TGF-1 activates fibroblasts through Smad2/3 signaling transduction, which results in increased expression of ECM components (fibronectin and vimentin) that further participate in the proliferation, migration, and trans-differentiation of fibroblasts into myofibroblasts that express a high level of -SMA 65 , VCN managed to reduce the expression of the fibrotic indices for ECM deposition and the signaling protein (Smad2/3) involved in the activation of fibroblasts and transitioning into ECM-producing myofibroblasts in MRC-5 induced with TGF-1