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In IDD, there is increased expression of matrix-degrading proteins such as matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTs) resulting in deregulation of the normal homeostatic mechanism (Le Maitre et al., 2007)

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doi: 10.1016/j.amjmed.2006.02.005

Therapy for a severe deficiency: 1000g Supply vs Intake: Not all Vitamin B12 can be Absorbed These rather high dosages are explained through the biological mechanism that enables the body to intake vitamin B12
