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Los polimorfismos genticos adicionales que ocurren en las rutas metablicas de colina y de un carbono pueden alterar el requerimiento diettico de colina y, por lo tanto, aumentar la probabilidad de desarrollar signos de deficiencia cuando la ingesta de colina es insuficiente (9, 20, 21)

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Increased anxiety-like behaviors and mitochondrial dysfunction in mice with targeted mutation of the Bcl-2 gene: further support for the involvement of mitochondrial function in anxiety disorders

Nibuya M, Morinobu S, Duman RS