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NAD+ levels naturally decline with age, which may contribute to feelings of fatigue and slower metabolism

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116 Lactate also inhibits histone deacetylase activity, leading to excessive H3K27 acetylation at Tcf7 super-enhancer sites, increasing Tcf7 expression

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[DOI] [PMC free article] [PubMed] [Google Scholar] 161.Shin J.W., Chun K.-S., Kim D.-H., Kim S.-J., Kim S.H., Cho N.-C., Na H.-K., Surh Y.-J

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