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Relevant to understanding the role of GPx-1 in mediating cell signaling, modest (approximately twofold) overexpression of GPx-1 in permanently transfected cells was found to be sufficient to decrease accumulation of intracellular ROS and attenuate EGFR-mediated signal transduction in response to hydrogen peroxide or its cognate ligand, EGF

Female-gender also has higher concentrations of some non-canonical amino acids like acetyl phenylalanine, 2-aminoadipic acid, N-acetyl aspartic acid, nicotinuric acid, aminosalicyluric acid in their urine [40], whereas male-gender have high concentrations of proline [40], leucine [41], l-carnosine, and 2,6-diaminopimelic acid [42]

J Dent Res (1990) 69(6):12669