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In this review we discuss the diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases

Selective activation of Ca2+-dependent PKCs by thymeleatoxin induces cholestasis and retrieval of Bsep from the canalicular membrane in the isolated perfused rat liver.144 Interestingly, the canalicular ATP-binding cassette transporter, multidrug resistance protein 1 (Mdr1), the closest homologue of Bsep, is phosphorylated by PKC at 3 serine residues at the C-terminal, linker region, which binds to the actin-associated protein, HAX-1.145 Whether this phosphorylation occurs also for Bsep remains to be ascertained

Clinical Application For patients with melasma, solar lentigines, or post-inflammatory hyperpigmentation (PIH), I recommend incorporating a daily topical antioxidant serum containing Vitamin C, paired with a skin-brightening agent like Arbutin

it will then be necessary to define the clinical impact of cross-reactivity among them