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found that higher levels of UA were associated with a lower risk of developing MCI during a 9-year follow-up [124]
For example, the formation of an isopeptide bond between the sidechains of lysine and glutamine is as follows: Gln(C=O)NH 2 + Lys-NH 3 + Gln(C=O)NHLys + NH 4 + The -amino group of lysine can also react with the -carboxyl group of any other amino acid as in the following reaction: Ile-(C=O)O + Lys-NH 3 + Ile-(C=O)NH-Lys + H 2 O Isopeptide bond formation is typically enzyme-catalyzed
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Ding H, Chang J, He F, Gai S, Yang P
