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Conversely, microbiome-derived indole derivatives are diminished in IBD 104 , and this metabolic trait has been linked to reduced mucosal barrier integrity and disturbed immune balance under disease conditions 124 , suggesting these metabolites for prophylactic and therapeutic treatments 131

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Accordingly, more than 173 million individuals around the world have PASC, based on a conservative estimated incidence of 25% of infected people and over 692 million documented COVID-19 cases globally 3,4,5

These compounds are thought to have a synergistic effect and are essential components necessary for many physiological systems within the body