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Lipoic acid has also been shown to improve nitric oxide (NO)-dependent vasodilation in aged rats by increasing PKB/Akt-dependent phosphorylation of endothelial NO synthase (eNOS) and eNOS-catalyzed NO production (47)

BLM-only treated animals showed a marked elevation in hydroxyproline (HYP) lung tissue content, which supports the marked increase in the lung weight index

The study was limited to people of European origin and may not apply to other populations, which may explain the reason why we did not find a causal association between SOD1 and ALS

In PCOS and benign disease models, comparisons with standard-of-care agents are still sparse