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These antibiotics accumulate within the endolymph, preferentially damaging outer hair cells in the basal cochlea, which results in high-frequency hearing loss, often the first detectable sign of aminoglycoside-induced ototoxicity (OSullivan et al

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10.4049/jimmunol.176.2.1046 78 MarosoM.BalossoS.RavizzaT.LiuJ.AronicaE.IyerA
