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PMID: 19238460 Prescription Information: rxlist.com (cocaine / topical) rxlist.com (Goprelto ) topical cocaine nasal spray Keywords Imipramine Trade Name: Tofranil Drug Class: TCA antidepressant (tricyclic amine) Mechanism of Action: Blocks presynaptic reuptake transporters for norepinephrine & serotonin (NET & SERT) on nerve endings (therapeutic effects) Antimuscarinic (contributes to side effects) Antihistamine (contributes to side effects) Alpha receptor blocking properties (contributes to side effects) Several weeks to months are required for antidepressant effects to appear (or be significantly greater than a placebo), although its direct effects (e.g

The DAC (drug affinity complex) version includes the maleimidopropionic acid linker that allows albumin binding

Taking both together in the morning on an empty stomach provides maximum absorption

Arora D, Bhatt S, Kumar M, Verma R, Taneja Y, Kaushal N, Tiwari A, Tiwari V, Alexiou A, Albogami S, Alotaibi SS, Mittal V, Singla RK, Kaushik D, Batiha GE