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Accumulating evidence has demonstrated that the eNOS dimer uncoupling increases pathologic ROS production and decreases NO synthesis by the endothelium 26

Glutathione S-transferases (GST) conjugate GSH to drugs and drug metabolites, thus facilitating drug-conjugate elimination and efflux

Mosunetu- zumab, teclistamab, epcoritamab, glofitamab and elranatamab include either an IgG1, IgG2 or IgG4 Fc domain (Table 2), which increases their molecular weight over that of tebentafusp (~145 kDa) and enables FcRn binding

Pfeiffer, Martin O
