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ER stress includes a major pathway called the unfolded protein response (UPR), controlling the accumulation of liver proteins and lipids in cells
[DOI] [PMC free article] [PubMed] [Google Scholar] Bukchin A
the BBB thus also limits the delivery of xenobiotics (such as drugs and diagnostic agents) to the brain, which complicates classical drug therapy (i.e
J Am Chem Soc 2020, 142 (23), 1050610515
