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Recently, the structure of erastin-bound xCT-4F2hc (4F2 cell-surface antigen heavy chain, SLC3A2, also called CD98) complex had been solved [37], which provides a molecular basis for drugs development targeting on SLC3A2
Therefore, a phage therapy strategy that leverages such a trade-off could result in improved clinical outcomes by decreasing bacterial burden and by selecting for surviving bacterial mutants that are less resistant to antibiotics or less virulent 8
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Gibson, B
