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The prevalence of pruritus varies depending on the underlying cause, with reports indicating rates of up to 70% in primary biliary cholangitis, 2.530% in chronic hepatitis C virus-related liver disease, and roughly 8% in cirrhosis attributed to hepatitis B virus infection ( Numerous hypotheses have been posited to elucidate the genesis of pruritus, albeit none deemed definitive

It has not been associated with significant immunosuppressive effects, instead demonstrating immunomodulatory activity by reducing pro-inflammatory cytokines like IL-6 and TNF-, without impairing normal immune function

Efforts should concentrate on expanding microbial collections to encompass a broader spectrum of M

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