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For example, iron generates hydroxyl radicals via the Haber-Weiss reaction and the Fenton reaction, which promote ROS formation, and acute myeloid leukemia (AML) cells induce ferroptosis in AML cells by increasing ROS levels via the HMGB1-regulated RAS-JNK/p38 signaling pathway [149]

Tofacitinib A meta-analysis of 17 studies (including 1,162 UC patients) reporting on real-world tofacitinib response rates, noted 8-week induction remission in 34.7% of patients (95% CI, 29.2%45.1%), with 6-month remission in 38.3% (95% CI, 29.247.5%)

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