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Development of the animal model was supported by a grant from the Simons Foundation to the late Dr
It was initially isolated from the cerebral venous blood of rabbits in an induced state of sleep and was shown to induce delta-wave sleep in rabbits when administered intravenously
HDAC9-mediated calmodulin deacetylation induces memory impairment in Alzheimers disease
The peptide is metabolized primarily by hepatic cytochrome P450 enzymes, with metabolites excreted renally
