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Furthermore, the combination of fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin with gemtuzumab ozogamicin has demonstrated an enhanced EFS in young patients with newly diagnosed AML, particularly in those with NPM1 or FLT3 mutations, resulting in a notable increase in the three-year OS rates to 82% and 64%, respectively [220]

Ar ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting gpx4-mediated redox homeostasis