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[12] Very high cumulative exposure over months may encourage calcium deposition in soft tissues such as the renal parenchyma or coronary arteries, an outcome implicated in observational studies linking supra-physiological 25-hydroxyvitamin D levels with vascular calcification and heightened fracture risk in frail elders

Monitoring Intake People with conditions that affect B12 absorption, such as pernicious anemia or gastrointestinal issues like Crohn's disease, should work with a healthcare provider to regularly monitor their B12 levels and adjust intake as needed