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A 2018 review in Cell Metabolism examined the therapeutic potential of NAD-boosting molecules across multiple in vivo models, highlighting emerging evidence for metabolic and neurological applications while emphasizing the need for larger human trials
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Klotho knockout mice, characterized by kidney disease and aging, also exhibited an increase in association with Beclin1 to BCL2, and a knockout of the disrupted Beclin1 improved autophagy and longevity in those mice [174]

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