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Description
Alpha-melanocyte-stimulating hormone (MSH) is a 13-AA (1SYSMEHFRWGKPV13) peptide with high affinity for MC1R [148]
Muscle loss stayed proportional
Sermorelin is a shorter analog

Semaglutide: FDA-approved for weight management (2021) and type 2 diabetes Widely available via prescription Available from research peptide suppliers Established insurance coverage pathways Years of post-marketing safety data Cagrilintide: Not FDA-approved (investigational as of March 2026) Phase 3 REDEFINE trials complete with positive results Available from some research peptide suppliers as a research chemical No insurance coverage Limited long-term safety data (68 weeks maximum from trials) Cost Considerations Without FDA approval, cagrilintide has no established retail price
