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Arsenite increased the number of autophagosomes and p70S6K, whereas 5-aza-deoxycytidine, a DNMT1 inhibitor, abolished the effect of arsenite on p70S6K expression (Huang et al., 2015)
Moderation and assessing individual risk are key
These results were in good agreement with our previous study on SCA31 showing the suppressive effects of FUS and other RBPs on RNA foci formation of UGGAA repeat RNA as RNA chaperones (Ishiguro et al., 2017), raising the possibility that FUS has RNA-chaperoning activity also for G 4 C 2 repeat RNA
