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14,15 Topical roflumilast is a selective, highly potent PDE4 inhibitor that is indicated for the treatment of several inflammatory dermatoses, such as seborrheic dermatitis, plaque psoriasis,

10.1126/science.8456300

doi: 10.1093/biolre/ioz180 62 PiltonenTTChenJEriksonDWSpitzerTLBarraganFRabbanJTet al

It is generally safe and effective
