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During metabolism most drugs lose the pharmacological activity and are excreted from the body
[DOI] [PMC free article] [PubMed] [Google Scholar] 277.Davies KN, King D, Billington D, Barrett JA
Dextromethorphan is a weak non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist resulting in glutamate inhibition and protected from first-pass metabolism by its co-drug, quinidine, which was shown to be well tolerated in patients with ALS [184]
& Howe, J
