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Recent studies have illustrated the role of the SIRT1-Nrf2-HO-1 pathway in the regulation of ferroptosis

172 In contrast, mitophagy serves as a preventative strategy against inflammation via eliminating damaged mitochondria and avoiding the production of excess ROS, hence the change in mitophagy will result in the alternation of inflammasome activation

Finally, the protein concentrations were determined using a Pierce BCA Protein Assay Kit

The central role of GPX4 in ferroptosis can be elaborated from multiple dimensions