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The average pixel intensity per worm compiled across 2 or more batch experiments was then plotted using GraphPad Prism 8.0 ( CRISPR/Cas9 generation of a C

I later learned that this is referred to as the heterodimer model: While I still use a graphic like this occasionally in slides when I am introducing the concept of autocatalytic post-translational conformational change to people who arent familiar with it, I think most prion scientists agree this isnt really what goes on

Because of the difficulty of obtaining complete urine collections, creatinine clearance calculated in this way is at least as reliable as estimates based on urine collections