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[DOI] [PubMed] [Google Scholar] Liang W, Austin S, Hoang Q, Fishman PH
Increased blood pressure and hyperdynamic cardiovascular responses in carriers of a common hyperfunctional variant of adenylyl cyclase 6
Comorbidities decrease physiological reserve, increasing the risk of life-threatening conditions
In overdose, the concentrations of 3-phosphoadenosine 5-phosphosulphate (PAPS) (for sulphation) and glutathione (for cytoprotection) are depleted, and extensive macromolecular binding leads to hepatocellular necrosis
