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Understanding irAEs With the advent of immunotherapy, oncologists and cancer researchers accustomed to the familiar, decades-old set of toxic side effects from chemotherapies and radiotherapy are being challenged with understanding and defining a new set of short-term and long-term side effects, referred to as irAEs, to provide timely and effective remedies to cancer patients experiencing them

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N.DayonL.et al (2017)

Protein Sol server was performed that showed deviation population average, charge per amino acid and fold propensity (Figure 4)