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Beyond small clinical cohorts, large-scale patient outcome data strongly supports the use of these compounds
Byun, J

Tick feeding was done as published [54] and approved in animal use protocols 2017-0068 and 2018-0001

The authors of this study reported increased expression of macrophage markers (f4/80 and CD68) and inflammatory cytokines (IL-6 and TNF) in the high fat diet (HFD) condition