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In the liver it is metabolized with the formation of N-methylnicotinamide, methylpyridonecarboxamides, glucuronide and complex with glycine

While formal drug interaction studies are limited, AOD-9604 can often be safely combined with other therapies under proper medical supervision

It's frequently referenced alongside MOTS-c and NAD+ in research contexts, given the complementary nature of their respective pathway interactions - particularly how NNMT inhibition influences NAD+ availability in metabolic signalling studies
